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Handel (bioinformatics software package) : ウィキペディア英語版 | Handel (bioinformatics software package)
Handel is a suite of programs for multiple sequence alignment. Since it is based on a model of DNA sequence evolution that explicitly incorporates insertion and deletion events, it effectively doubles as a program for ancestral sequence reconstruction. The theory underpinning Handel is based on the finite state transducer, a concept borrowed from computational linguistics. Handel can be downloaded as part of the (DART software package ). It accepts input files in (Stockholm ) format. ==References==
* Holmes I, Bruno WJ. (Evolutionary HMMs: a Bayesian approach to multiple alignment ). Bioinformatics. 2001 Sep;17(9):803-20. * Holmes I. (Phylocomposer and Phylodirector: Analysis and Visualization of Transducer Indel Models. ) Bioinformatics. 2007
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